Continuing Education Activity
The osteopathic manipulative principles for high-velocity low amplitude (HVLA) cervical spine therapy include the indications for treatment, treatment techniques, and the expectations of resolution of symptoms. HVLA cervical manipulation techniques can provide another outlet for patients with cervical neck dysfunction in addition to traditional medical routes. This activity will review the candidacy evaluation of the patient's cervical pathology and provide the significance of communication between the physician and the patient for optimal outcomes of cervical spine HVLA.
Objectives:
Outline the steps of the high-velocity low amplitude thrust as an alternate treatment for patients with cervical joint dysfunction.
Evaluate the methods ofhigh-velocity amplitude thrust treatment for the cervical spine.
Assessthe indications for high-velocity low amplitude thrust treatment of the cervical spine.
Introduction
Since the founding of osteopathy by Andrew Taylor Still, M.D., D.O. in 1874, a fundamental principle of osteopathic medicine has been the treatment of somatic dysfunction by using osteopathic manipulative treatment (OMT).[1] Somatic dysfunction is an impaired function of integral components of the somaticsystem (the body framework). It can include the musculoskeletal, nervous, vascular, and lymphatic systems and combinations of these systems in affected areas of dysfunction.[1][2]
High-velocity low amplitude (HVLA)OMT is one technique utilized by various practitioners to restore health to the somatic system. Specifically, HVLA therapy is a technique used in manual medicine that employs a rapid, therapeutic force of brief duration that travels a short distance within a joint's anatomic range of motion. The force engages a restrictive barrier to elicit a release of the restriction. HVLA treatment is frequently associated with an audible and palpable "release" in the form of a "pop" accepted to represent cavitation of a spinal intervertebral joint and its subsequent release.
The cervical (neck) region comprises vascular, musculoskeletal, and neural pathways between the cranium and the thorax. It is a common area of injury and somatic dysfunction, resulting in pain and loss of mobility. Understanding the diagnostic approach and the treatment of cervical spinal somatic dysfunction is a cornerstone ofmanual medicine.
Dysfunction may occur at1 or many anatomical locations: the atlantooccipital joint, the atlantoaxial joint, the paraspinal musculature, or other cervical vertebral joints.OMT may include various myofascial release techniques, muscle energy techniques, strain-counter strain techniques, and HVLA techniques. HVLA is used to relieve movement restrictions by applying a quick, therapeutic force of rapid duration that travels a short distance within the range of motion of a joint. HVLA therapy aims to restore a more "normal" range of motion within a joint and alleviate pain.
Neck dysfunction is associated with significant health costs and disability, typically due to work-related injuries and improper ergonomic practices.[3] Cervical musculoskeletal joint dysfunction symptoms include neck pain, stiffness, loss of neck mobility, arm pain, tingling in the upper extremities, weakness, dizziness, and headache.
HVLA OMT of the cervical spine is a passive, direct therapy that provides anHVLA manually applied force to treat motion loss in a somatic dysfunction.[4] Passive treatment implies that the patient stays inactive throughout this therapy and does not attempt to assist the physician in executing cervical HVLA treatment. This therapy provides direct engagement into the restrictive barrier of the cervical spine. The treatment goal is to forcefully stretch a contracted musculoskeletal system, producing an aggressive response of afferent nerve impulses from the muscle spindles to the central nervous system. The central nervous systemsends a reflex of inhibitory responses to the muscle spindle, relaxing the muscle.[5][3]
HVLA therapy of the cervical spine should be performed only by practitioners who have been educated with this technique and have demonstrated practical and cognitive skills. Like any other procedure, education, pre-procedural screening for contraindications, and a detailed review of the risks and benefits are imperative before HVLA treatment.Informed consent to medical treatment is fundamental in both ethics and law. Patients can receive advice and ask questions about HVLA treatments to make well-founded decisions.[6]
Anatomy and Physiology
The cervical spine has 7 vertically stacked bones called vertebrae, labeled C1 (cervical 1) through C7 (cervical 7). C1 (called the atlas) connects the top of the cervical spine to the base of the skull, and C7 connects to the upper thoracic spine at about shoulder level. These uniquely shaped bones (the spinal column) protect the spinal cord, acylindrical bundle of nerve fibers and associated nerve roots enclosed within the cervical vertebrae, connecting the body to the brain.
The upper cervical spine is unique. The atlas (C1) and axis (C2), functioning together, are primarily responsible for spinal rotation, flexion (bend forward), and extension (bend backward) and are the most mobile part of the entire spine. Roughly 50% of flexion and extension and 50% of neck rotation occur in the areas of C1 and C2. The remainder of the cervical vertebrae (C3-C7) are smaller than the thoracic and lumbar vertebrae. The vertebral bodies are round with a hollow center that continues from C1 and C2 and houses the spinal cord as it travels distally from the brainstem. The cervical intervertebral discs are "shock-absorbing pads" between each level starting below C2 (axis). The discs are strong yet flexible tissues composed of fibrocartilage. In the middle of each disc is a nucleus pulposus, a gel-like material surrounded by a strong protective outer layer called the annulus fibrosus.
At each vertebral level of the spinal column, the discs hold the vertebrae together and absorb shock to the spine. The discs also create spaces (called foramen) between each bony vertebrae, allowing nerves to exit the spinal cord. Spinal nerve roots are bundles of nerve fibers that exit (or enter) the spinal cord in pairs from each side of the spinal cord and travel through the foramen to send and receive nerve impulses from the body. Each cervical nerve innervates or provides sensation and motor function to both sides of a corresponding part of the upper body. Muscles, tendons, and ligaments help support the cervical spinal column by limiting excessive movement in all directions.
Common disc disordersinclude degenerative disc disease and disc herniations ("ruptured disc") that can cause adjacent spinal nerve irritation. This can happen when a disc flattens or becomes deformed, as the space for a spinal nerve passing through the foramen is compromised. Nerve compression may cause pain radiating throughout the neck and into the head, back, and arms. Cervical spinal stenosisis a narrowing of the hollow center of the spinal canal. It can lead to spinal cord compression and impingement of the nerve roots exiting the spinal cord. Cervical traumamay affect the cervical spinal column by causing injury to bones, nerves, muscles, tendons, and ligaments. Trauma can disrupt nerve communication between the brain and various somatic and visceral systems, sometimes resulting in weakness, paralysis, and loss of sensation.Cervical strain is typically the result of a stretch injury to the muscles and ligaments of the cervical spine. Oftentimes, it is the result of trauma from sports-related injuries, falls, or motor vehicle accidents. Prolonged improperpositioning (poor workplace ergonomics) can cause postural deviations, which may eventually result in neck pain even in younger patient populations.[7]
To be an adequate cervical HVLA OMT provider, the provider must have adequate knowledge of cervical spine and neck anatomy.[8]It should be noted that all cervical vertebrae except C1 and C2 are composed of2 portions: The body (an anteriorly situated central mass of bone) and a vertebral arch arising posteriorly off the body. The vertebral arch consists of the pedicles that connect the body to the articular processes and the lamina that connects the articular processes to the spinous process on the most posterior aspect of each vertebra. The paired articular processes on each vertebra articulate with an adjacent articular process of a contiguous vertebra to form zygapophyseal joints, allowing motion between the vertebrae in X, Y, and Z planes.
The transverse processes are small bony projections off each vertebra's right and left sides. The2 transverse processes of each vertebra function as the site of attachment for muscles. The transverse foramen (foramen transversarium) of the cervical vertebrae is a hole or opening in the transverse process of a cervical vertebra for the passage of the vertebral artery and vein and the sympathetic nerve plexus. The paired vertebral arteries (1 on each side) are of particular importance because they provide blood to the brain and spinal cord, and they can be damaged during traumatic events involving the transverse processes. The spinous process is a bone projection off the posterior aspect of a vertebra. It arises from the neural arch at the junction of2 laminae and provides attachment for muscles concerned with flexion, extension, and spine stability. Efficient and careful palpation of the cervical vertebral elements, particularly the spinous and transverse processes, is essential to establish an accurate diagnosis of cervical somatic dysfunction. Likewise, the same knowledge base is required to provide cervical HVLA OMT for the patient in the safest way possible.
Indications
Many manual medicine practitioners use HVLA thrust techniques to treat spinal somatic dysfunction. A common indication for HVLA OMT is "joint fixation," a condition where any2 bones in a joint become misaligned or fixated (stuck). HVLA therapy in the cervical region may effectively resolve neck, shoulder, and head pain.[9]HVLA therapy of the cervical spine is indicated to treat motion loss with associated somatic dysfunction. It is hypothesized that fibrous adhesions develop in zygapophyseal joints during relative immobility periods, restricting joint motion. HVLA therapy is thought to improve symptoms consistent with musculoskeletal joint restriction due to cavitation and adhesions of the zygapophyseal joints. HVLA is typically used for patients with local or radiating neck pain in non-acute phases. To that extent, it is also used to treat patients with cervicogenic headaches.Studies suggest that mobilization or manipulation of the cervical spine may benefit individuals experiencing cervicogenic headaches.[10]
Contraindications
There are2 types of contraindications in the cervical HVLA OMT: absolute and relative. Absolute contraindications include patients with a medical history of osteoporosis, active osteomyelitis, fractures in the cervical area, severe rheumatoid arthritis, and bone metastasis in the cervical region. Also included are patients with Down Syndrome, as HVLA therapy can lead to rupture of the transverse ligament of the dens process since this population may have increased laxity of the transverse ligament at baseline.[11]
Absolute Contraindications:[12][13]
Acute fractures
Acute soft tissue injury
Acute myelopathy
Ankylosing spondylitis
Anticoagulant therapy
Chiari malformation
Connective tissue disease
Dislocation
Down syndrome
Infection
Instability
Ligament rupture
Osteoporosis
Patient refusal
Recent surgery
Rheumatoid arthritis
Surgical or pathologic fusion of a joint
Tumor/bony malignancy
Vertebral artery abnormalities
Vascular disease
Relative Contraindications:[13]
Acute herniated nucleus pulposis
Acute whiplash
Any symptom aggravated by movement of the neck
Blurred vision
Diplopia
Dizziness/vertigo
Drop attacks
Dysarthria
Dysphagia
Facial/oral paresthesia
Hypermobility syndromes
Nausea
Previous diagnosis of vertebrobasilar insufficiency
Tinnitus
Visual disturbances
Worsening of symptoms with manipulations
Since a large number of the reported cases of serious adverse outcomes involved cervical HVLA OMT and "thrust" techniques involved vertebrobasilar accidents (VBA) and strokes, caution should be used when treating patients with suspected artery disease or vascular anomalies.[14][15][16]
Personnel
The technique requires practitioner training in OMT or hands-on spinal manipulation techniques. To have successful HVLA therapy outcomes, the patient must consent, be cooperative, and be relaxed andhealthy enough to be placed in the proper position for treatment.
Preparation
It is encouraged that all practitioners who wish to use cervical manipulation should undertake a formal education program to decrease risks.[12]As with any therapy, awareness and knowledge are important factors in weighing the benefits, managing the risks, and recognizing early warning signs of adverse events.[17]Preparation should begin with a thorough history and complete head-to-toe assessment to minimize the likelihood of complications arising from cervical manipulation. Patients should be thoroughly screened for all potential contraindications and precautions, preferably through screening methods focused on identifying patients who have contraindications to HVLA therapy and may be at risk of adverse outcomes.[12][13]
Since HVLA OMT is considered a procedure, proper consent should be obtained before the initiation of treatment.[18] Providing information about HVLA and assessing the patient's understanding of HVLA is essential to positive outcomes and patient relaxation during the procedure. The practitioner's duty includes the safe and appropriate performance of HVLA therapy and providing pertinent information and advice to enable the patient to make an informed decision regarding their treatment. Failure to inform the patient of the potential risks and benefits and failure to obtain informed consent is a breach of duty. Preparation starts with localizing the correct region in which a cervicalsomatic dysfunctionexists. To establish this diagnosis, it is necessary to identify the specific cervical spine level at which the segment is causing severe pain on palpation or a restriction of motion. Once identified, the practitioner engages that cervical level in both flexion and extension. The provider then tests the patient's ability to rotate and side-bend each segment to the right and left. Once identifying the restricted barrier, for example, a C4 vertebra that is flexed, rotated left side bent left, the physician would take the restricted barrier into the opposite orientation. For this example, you would engage C4 extended rotated right and side bent right.
Patient positioning is ideal for optimal procedural outcomes. The patient should be supine, and the operator (physician) should be at the head of the table. Patients need to be as relaxed as possible during physical assessment. This is an essential component of treatment for patients to have optimal results and prevent any adverse outcomes. A satisfactory patient-physician relationship and a foundation of trust are imperative to positive outcomes.
Technique or Treatment
A Step-by-step organized procedural pathway is paramount to an ideal outcome for this procedure. The first step is diagnosing the patient's cervical somatic dysfunction. Then, verifying that there are no existing contraindications ensures that the patient is a candidate for HVLA therapy.Diagnosing cervical somatic dysfunction involves a careful manual examination of the atlantooccipital joint with the patient in the supine position, comparing the depths of theoccipital sulci. The atlantoaxial joint is examined by flexing the patient's cervical spine and locking the atlantooccipital and C2-C7 joints. The range of motion of the atlantoaxial joint is then evaluated by slowly rotating the cervical spine from right to left, noting any restricted movement when comparing the rotation to each side. C2-C7 are also evaluated with the patient in the supine position, with careful attention directed to the freedom of movement of each segment with palpation to the right and left. With the cervical spine positioned in the neutral, flexed, and extended positions, the practitioner should determine which segments are rotationally translated (manually displaced) more easily from1 side versus the contralateral side. A lack of equality at any translation level of an individual vertebra indicates a restriction.
HVLA techniques are most successful when the patient is relaxed. Myofascial techniques may be instituted before HVLA therapy to relax muscle groups further. This is achieved by applying a slow and gentle force to loosen hypertonic muscles. By delivering perpendicular and parallel traction and stretching motions with the fingertips, the muscles and soft tissues "release." When the restricted barrier is identified (for example, C4 flexed rotated left, side bent left), the practitioner takes the restricted barrier into the opposite orientation. In this example, the practitioner would engage C4 in the extended, rotated right, and side-bent right position.
The patient is instructed to relax. If the patient does not adequately relax, the treatment will fail, and the corrective thrust cannot be executed appropriately. The physician should instruct the patient to take multiple deep breaths, further engaging the restrictive barrier in the exhalation phase. The physician then executes ashort, effective thrust to move the dysfunctional segment through the restriction barrier. The ability to perform a successful adjustment with HVLA therapy sometimes elicits a "popping" sound. The restrictive barrier should be engaged entirely before applying the thrust. Finally, after executing the HVLA technique, the practitioner should reassess the range of motion and the somatic dysfunction treated. A successful result would lead to approximately 70% or greater return in the restricted range of motion and/or relief of pain. Patientsare discharged after thirty minutes of observation with instructions to hydrate appropriately. They follow up in 1week for further evaluation and reassessment.
Complications
Although rare, the risk of catastrophic adverse effects has been associated with manual therapy of the cervical spine. The most serious associated adverse events include cervical artery dissection, vertebrobasilar insufficiency, and artery spasm, all of which can lead to stroke.[19]It is suggested that all practitioners perform aVertebral Artery Test (Wallenberg test), a physical exam for vertebral artery insufficiency before neck manipulation. The Wallenberg test involvesmotion in the cervical spine in the position of rotation, extension, and a combination of both.If the patient has vertebral artery insufficiency symptoms during the test (lightheadedness, visual disturbance, or ocular nystagmus), it is considered a positive result, and cervical manipulation should be avoided.[20]
Controversy surrounds the dependability of vertebral artery testing before manipulation, with studies concluding that it is impossible to conclude the accuracy of pre-manipulative tests. Studies may indicate that pre-manipulative tests are unreliable screening procedures.[21] Nevertheless, the possibility of vertebral artery disease must be entertained before performing cervical manipulation. Vertebral artery injury is a major complication, usually occurring when cervical HVLA is performed with the neck in the extended position.[22]Vertebral artery dissections may occur due to intimal damage resulting from over-stretching the artery during rotational maneuvers.[23]Intimal injury can lead to bleeding into the wall of the artery, pseudoaneurysm formation, thrombosis, and embolism.[24]
Additional complicationsof this procedure, mainly performed by providers without sufficient experience, can include minor soreness or muscle pains. Complications are rare, but the chance of adverse events increases with contraindications. Additional complications can include fractures of cervical vertebrae, spinal cord injury, and other soft tissue injuries.[25] In some cases, subjective pains may be made worse following an HVLA therapy. It is also hypothesized that dural tears may infrequently occur following HVLA treatment and central retinal artery occlusions from patients with atherosclerotic disease of the carotid arteries and spinal cord contusion (Brown-Sequard syndrome).[26][27][28]
Clinical Significance
Various professions frequently use the HVLA, including physicians, chiropractors, physical therapists, and other manual medicine practitioners. HVLA therapy is also called the "thrust" technique since it directsa quick, short thrust through a joint, typically in the spine. Thegoal of HVLA OMT of the cervical spine is the resolution of symptoms (reduced pain, increased range of motion).The frequently cited therapeutic mechanism of HVLA treatment centers on restoring joint mobility and/or correcting a joint's malalignment.[29]With this in mind, some believe that the therapeutic effect of HVLA therapy is the result of a reduction of pain from some underlying painful biomechanical dysfunction (a corrective treatment of a painful biomechanical lesion).[30]
Controversy exists since evidence suggests that treating the asymmetrical movement of a single vertebral segment or multiple segments is unlikely to have a therapeutic effect and that treating spinal segments only produces a "minor movement" already observed in the pre-treatment segments.[29][31]In attempting to describe the mechanism of action of HVLA, researchers propose that HVLA provides relief through a complex reflexive pathway involving afferent and efferent neurons and their effects on local paraspinal regions. Furthermore, HVLA may help decrease pain by triggering serotonin and noradrenaline release on a systemic level.[32]Studies have suggested that osteopathic manipulative treatment, in general, is as efficacious as intramuscular ketorolac inproviding pain relief.[33]To that extent, it was concludedthat OMT is a reasonable alternative to parenteral nonsteroidal anti-inflammatory medications for patients with acute neck pain. Nevertheless, thereis a need for further osteopathic trials with specific outcome measures related to the HVLA technique to define the therapeutic effect better and define what combination therapies might best benefit the patient.[34]
Enhancing Healthcare Team Outcomes
The patient-physician relationship is built on trust, allowing a physician to provide an accepted standard of care within the practitioner's scope of practice and training.[35][36][37]To that extent, communication between the physician providing HVLA OMT and the patient is pivotal for optimizing results. The physician's responsibility is to educate, provide adequate information about the risks and benefits of treatment, and obtain informed consent before this procedure to alleviate anxiety. This allows maximal relaxation and comfort, which are essential to proper performance. Successful communication in the patient-physician relationship ensures trust and allows for shared decision-making.
Collaboration amongst the interprofessional team to understand and interpret somatic dysfunctions and HVLA therapy is paramount to guide further diagnostics, therapeutics, and consultations for the patient's overall benefit. Collaboration with other members of the healthcare team (other physicians, as well as physical therapists, occupational therapists, social workers, acupuncturists, counselors, etc) may ensure complementary healthcare modalities, such as dietary changes, nutritional supplements, therapeutic exercises, and medicinal regimes as part of the overall treatment plan.
Review Questions
References
- 1.
Ingold CJ, Ratay S. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Jul 31, 2023. Osteopathic Manipulative Treatment: HVLA Procedure - Inhaled Ribs. [PubMed: 32965970]
- 2.
Snider KT, Johnson JC, Snider EJ, Degenhardt BF. Increased incidence and severity of somatic dysfunction in subjects with chronic low back pain. J Am Osteopath Assoc. 2008 Aug;108(8):372-8. [PMC free article: PMC2592088] [PubMed: 18723455]
- 3.
Giacalone A, Febbi M, Magnifica F, Ruberti E. The Effect of High Velocity Low Amplitude Cervical Manipulations on the Musculoskeletal System: Literature Review. Cureus. 2020 Apr 15;12(4):e7682. [PMC free article: PMC7228797] [PubMed: 32426194]
- 4.
Dugailly PM, Sobczak S, Van Geyt B, Bonnechère B, Maroye L, Moiseev F, Rooze M, Salvia P, Feipel V. Head-trunk kinematics during high-velocity-low-amplitude manipulation of the cervical spine in asymptomatic subjects: helical axis computation and anatomic motion modeling. J Manipulative Physiol Ther. 2015 Jul-Aug;38(6):416-24. [PubMed: 26215899]
- 5.
Lyle MA, Nichols TR. Evaluating intermuscular Golgi tendon organ feedback with twitch contractions. J Physiol. 2019 Sep;597(17):4627-4642. [PMC free article: PMC6717046] [PubMed: 31228207]
- 6.
Hall DE, Prochazka AV, Fink AS. Informed consent for clinical treatment. CMAJ. 2012 Mar 20;184(5):533-40. [PMC free article: PMC3307558] [PubMed: 22392947]
- 7.
Gheysvandi E, Dianat I, Heidarimoghadam R, Tapak L, Karimi-Shahanjarini A, Rezapur-Shahkolai F. Neck and shoulder pain among elementary school students: prevalence and its risk factors. BMC Public Health. 2019 Oct 16;19(1):1299. [PMC free article: PMC6796365] [PubMed: 31619204]
- 8.
Wang X, Lindstroem R, Carstens NP, Graven-Nielsen T. Cervical spine reposition errors after cervical flexion and extension. BMC Musculoskelet Disord. 2017 Mar 13;18(1):102. [PMC free article: PMC5347814] [PubMed: 28288610]
- 9.
Saavedra-Hernández M, Castro-Sánchez AM, Fernández-de-Las-Peñas C, Cleland JA, Ortega-Santiago R, Arroyo-Morales M. Predictors for identifying patients with mechanical neck pain who are likely to achieve short-term success with manipulative interventions directed at the cervical and thoracic spine. J Manipulative Physiol Ther. 2011 Mar-Apr;34(3):144-52. [PubMed: 21492749]
- 10.
Garcia JD, Arnold S, Tetley K, Voight K, Frank RA. Mobilization and Manipulation of the Cervical Spine in Patients with Cervicogenic Headache: Any Scientific Evidence? Front Neurol. 2016;7:40. [PMC free article: PMC4800981] [PubMed: 27047446]
- 11.
Van Dyke DC, Gahagan CA. Down syndrome. Cervical spine abnormalities and problems. Clin Pediatr (Phila). 1988 Sep;27(9):415-8. [PubMed: 2970908]
- 12.
Refshauge KM, Parry S, Shirley D, Larsen D, Rivett DA, Boland R. Professional responsibility in relation to cervical spine manipulation. Aust J Physiother. 2002;48(3):171-9; discussion 180-5. [PubMed: 12217065]
- 13.
Puentedura EJ, March J, Anders J, Perez A, Landers MR, Wallmann HW, Cleland JA. Safety of cervical spine manipulation: are adverse events preventable and are manipulations being performed appropriately? A review of 134 case reports. J Man Manip Ther. 2012 May;20(2):66-74. [PMC free article: PMC3360486] [PubMed: 23633885]
- 14.
Assendelft WJ, Bouter LM, Knipschild PG. Complications of spinal manipulation: a comprehensive review of the literature. J Fam Pract. 1996 May;42(5):475-80. [PubMed: 8642364]
- 15.
Jones J, Jones C, Nugent K. Vertebral artery dissection after a chiropractor neck manipulation. Proc (Bayl Univ Med Cent). 2015 Jan;28(1):88-90. [PMC free article: PMC4264725] [PubMed: 25552813]
- 16.
Chen WL, Chern CH, Wu YL, Lee CH. Vertebral artery dissection and cerebellar infarction following chiropractic manipulation. Emerg Med J. 2006 Jan;23(1):e1. [PMC free article: PMC2564146] [PubMed: 16373786]
- 17.
Rushton A, Rivett D, Carlesso L, Flynn T, Hing W, Kerry R. International framework for examination of the cervical region for potential of Cervical Arterial Dysfunction prior to Orthopaedic Manual Therapy intervention. Man Ther. 2014 Jun;19(3):222-8. [PubMed: 24378471]
- 18.
Delany C. Cervical manipulation--how might informed consent be obtained before treatment? J Law Med. 2002 Nov;10(2):174-86. [PubMed: 12497733]
- 19.
Di Fabio RP. Manipulation of the cervical spine: risks and benefits. Phys Ther. 1999 Jan;79(1):50-65. [PubMed: 9920191]
- 20.
Richter RR, Reinking MF. Evidence in practice. How does evidence on the diagnostic accuracy of the vertebral artery test influence teaching of the test in a professional physical therapist education program? Phys Ther. 2005 Jun;85(6):589-99. [PubMed: 15921479]
- 21.
Hutting N, Verhagen AP, Vijverman V, Keesenberg MD, Dixon G, Scholten-Peeters GG. Diagnostic accuracy of premanipulative vertebrobasilar insufficiency tests: a systematic review. Man Ther. 2013 Jun;18(3):177-82. [PubMed: 23127991]
- 22.
Hidalgo B, Hall T, Bossert J, Dugeny A, Cagnie B, Pitance L. The efficacy of manual therapy and exercise for treating non-specific neck pain: A systematic review. J Back Musculoskelet Rehabil. 2017 Nov 06;30(6):1149-1169. [PMC free article: PMC5814665] [PubMed: 28826164]
- 23.
Ernst E. Adverse effects of spinal manipulation: a systematic review. J R Soc Med. 2007 Jul;100(7):330-8. [PMC free article: PMC1905885] [PubMed: 17606755]
- 24.
Nadgir RN, Loevner LA, Ahmed T, Moonis G, Chalela J, Slawek K, Imbesi S. Simultaneous bilateral internal carotid and vertebral artery dissection following chiropractic manipulation: case report and review of the literature. Neuroradiology. 2003 May;45(5):311-4. [PubMed: 12692699]
- 25.
Chakraverty J, Curtis O, Hughes T, Hourihan M. Spinal cord injury following chiropractic manipulation to the neck. Acta Radiol. 2011 Dec 01;52(10):1125-7. [PubMed: 22025741]
- 26.
Jeret JS. More complications of spinal manipulation. Stroke. 2001 Aug;32(8):1936-7. [PubMed: 11486132]
- 27.
Jumper JM, Horton JC. Central retinal artery occlusion after manipulation of the neck by a chiropractor. Am J Ophthalmol. 1996 Mar;121(3):321-2. [PubMed: 8597278]
- 28.
Lipper MH, Goldstein JH, Do HM. Brown-Séquard syndrome of the cervical spinal cord after chiropractic manipulation. AJNR Am J Neuroradiol. 1998 Aug;19(7):1349-52. [PMC free article: PMC8332220] [PubMed: 9726481]
- 29.
Hennenhoefer K, Schmidt D. Toward a Theory of the Mechanism of High-Velocity, Low-Amplitude Technique: A Literature Review. J Am Osteopath Assoc. 2019 Oct 01;119(10):688-695. [PubMed: 31566696]
- 30.
O'Neill S, Ødegaard-Olsen Ø, Søvde B. The effect of spinal manipulation on deep experimental muscle pain in healthy volunteers. Chiropr Man Therap. 2015;23:25. [PMC free article: PMC4561471] [PubMed: 26347808]
- 31.
Ianuzzi A, Khalsa PS. Comparison of human lumbar facet joint capsule strains during simulated high-velocity, low-amplitude spinal manipulation versus physiological motions. Spine J. 2005 May-Jun;5(3):277-90. [PMC free article: PMC1315283] [PubMed: 15863084]
- 32.
Skyba DA, Radhakrishnan R, Rohlwing JJ, Wright A, Sluka KA. Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord. Pain. 2003 Nov;106(1-2):159-68. [PMC free article: PMC2732015] [PubMed: 14581123]
- 33.
McReynolds TM, Sheridan BJ. Intramuscular ketorolac versus osteopathic manipulative treatment in the management of acute neck pain in the emergency department: a randomized clinical trial. J Am Osteopath Assoc. 2005 Feb;105(2):57-68. [PubMed: 15784928]
- 34.
Zamora S, Seffinger MA. Cervical HVLA Used as Single Intervention Improves Motion and Strength. J Am Osteopath Assoc. 2018 May 01;118(5):346-348. [PubMed: 29710358]
- 35.
Honavar SG. Patient-physician relationship - Communication is the key. Indian J Ophthalmol. 2018 Nov;66(11):1527-1528. [PMC free article: PMC6213668] [PubMed: 30355854]
- 36.
Pellegrini CA. Trust: The Keystone of the Patient-Physician Relationship. J Am Coll Surg. 2017 Feb;224(2):95-102. [PubMed: 27773776]
- 37.
Epstein RM, Franks P, Fiscella K, Shields CG, Meldrum SC, Kravitz RL, Duberstein PR. Measuring patient-centered communication in patient-physician consultations: theoretical and practical issues. Soc Sci Med. 2005 Oct;61(7):1516-28. [PubMed: 16005784]
Disclosure: Bader Elder declares no relevant financial relationships with ineligible companies.
Disclosure: Kevin Tishkowski declares no relevant financial relationships with ineligible companies.